CultureHouse is a adventure game inspired by biological cultivation experiments, 20th-century modernist architecture, and the dépayssement of surrealism.

You will live for 7 days in a residential research facility called CultureHouse, where a missing biochemist once resided, nurturing a mysterious lifeform known as Geneo.

As you progress in cultivating Geneo, you'll engage in conversations with visiting characters related to CultureHouse and observe strange occurrences happening in the surroundings. Gradually, the serene life transforms into something peculiar.

The story, which once concluded with your death (or the world's catastrophe), restarts from the morning of the first day when you visits CultureHouse, and the growth of Geneo takes on different forms based on the your choices.

Experiencing several catastrophic endings, you delve into the enigmatic connection between the tragic past events at CultureHouse, the world heading towards doom, and Geneo, using clues from the notes left by the biochemist and conversations with visiting characters.