In the late Eastern Han Dynasty, a mysterious illness ravages the land, bringing continuous disasters and wars. In such dire times, death may seem like a blessing. Enter a girl who claims to be the true Hua Tuo, the renowned physician Zhang Zhongjing who longs for peace, and Dong Feng, the medical master behind Qing Nang Shu and Shanghan Lun. These three individuals, each from different walks of life, unite on a tumultuous journey, their fates intertwined. After enduring great sorrow and sacrifice, can they uncover the truth and stop the mastermind behind the calamities?

Throughout your journey, you will treat a variety of patients and navigate the world of figures like Cao Cao and Yuan Shao, biding your time to unveil the massive conspiracy lurking behind the epidemic.