Use different cards to obliterate your foes and avoid their unique abilities. 

Make split-second decisions that impact the combat and long-term ones to collect cards that synergize with each other. 

Medieval times bring medieval challenges... harvest the power of the Black Death to decimate your foes!
But beware, as its blight may consume you.

Choose different backgrounds and ascension-driven debuffs to make each run different from the last.