This game is a Mahjong tournament against girls (most of then doctors/nurses) from the games of the popular Innai Kansen series. This game has no big own story. Simply challenge one girl after the other and enjoy the graphics as well as their voice-acted embarrassment.
The game offers two modes of playing:
1.) VS-MODE, that lets you each time challenge only one out of ten girls and play against her a one-on-one-mahjong with japanese rules. In addition to that, this game offers also a system of "magical (or rather medical)" items that could be bought at the beginning of each challenge. Those items could been used in game as "magic attacks", that modify the coincidental factors of the game to the players advantage.
2.) TRIAL MODE, that lets you select three out of twelve girls for a regular 4-players mahjong with japanese rules. By beating all 10 girls in the VS MODE, the TRIAL MODE becomes unlocked.

[From Unicorn review]