Blood: The Last Vampire is part of the Yarudora (やるドラ) game series which are meant to be played as an interactive anime. As is the case with earlier games in the series, Blood: The Last Vampire features full voice-acting and plays non-stop as a regular TV anime with player choices which need to be selected in a time limit of only a couple of seconds and result in story branching or slight alteration of the events. The game has multiple endings and by re-playing it, more choices and ending get unlocked. There is a flowchart show the overall story progress and taken routes so replaying does not become repetitive.

The PSP release of Blood: The Last Vampire is a compilation of first (上巻) and last volume (下巻) which were released as two separate games for PlayStation 2. In addition the PSP release has doubled the CG gallery and also includes special movie edits for each of the three heroines which can be unlocked by completing the game.

Based on the manga and anime movie with the same title, this game focuses on the story set in Tokyo a couple of decades after the original series. While the anime and game stories don't have direct connection, the game setting is based on the same world as in the original series. While Saya is the protagonist of the original story, this story features a young boy who is a high-school student, as the protagonist. One day, while riding a subway, he experiences the strangest sensation... he starts hearing a demonic voice that no one else can hear. This soon starts to affect his daily life and drive him towards madness, but then Saya, the last remaining original vampire enters his life.

Source: Mobygames