3x3 Eyes ~Sanjiyan Henjou~ is based on the manga and anime series 3x3 Eyes. Pai, a young girl from the immortal tribe of sanzhiyan, three-eyed demons of Chinese origin, wants to become a human again. She meets a Japanese teenager named Yakumo Fujii, whom she accidentally turns into a "wu", an immortal obedient servant of a three-eyed demon. Together, Pai and Yakumo try to regain their lost humanity.

This game can be considered a side-story to the series. The player does not control Yakumo, but an ordinary high-school student named Kenichi Yamamoto. Accidentally, Kenichi comes into contact with the world of demons, and now he needs the help of Pai and Yakumo to be freed.

[From Moby Games]