Two years after the end of the Danganronpa TV show, and one year after the events of Danganronpa: LIVe or Die, a huge meetup event for survivors of the various seasons is held. However, someone releases sleeping gas and kidnaps 16 of the attendees to put them in a new killing game on a deserted island. What they don't initially realize is that all of them won their respective seasons by committing murder and getting away with it - so everyone in this game is already a killer!

The protagonist, Rui, is the Ultimate Danganronpa Fan - but will that talent be enough to help him survive Danganronpa for the second time?